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TZ-GF101

Targeted Signaling for Organoids and Hair Follicle

Our completely de novo designed Wnt surrogate selectively and potently binds Fzd7
subtype members only to precisely activate Wnt signaling in specific stem cells.

It promotes robust organoid growth from intestinal stem cells, and induces robust hair
growth in mice, offering a versatile tool for organoid cultures and regenerative medicine.

Firefly_A premium 3D render of a spherical hair follicle cell with an elegant glass-like m

Mode of action 

Day 0

Day 14

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Vehicle

0.1 uM

1 uM

4 uM

Functional validation
completed in animal models
(robust hair growth)

Progress

Design

Lead

Validation

Remarks

Asset

Wnt surrogate

Publication

De Novo design of a potent Wnt Surrogate specific for the Frizzled7 subtype members

 

Junyup Lee, Yeongnam Bae, Tae-Keun Jeong, Seokmin Yun, Jeeyoon Chang, SangPhil Ahn, Hyeongyu Han, Jieun Mun, Seung Jun KimHo Min Kim, Dae-Sik Lim, Yoon Ki Kim, Eui-Jeon Woo, Hanseul Yang, Ho-Chul Shin, Bo-Seong Jeong, Byung-Ha Oh

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