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Firefly_High-resolution 3D protein model within a glowing electron density map, _soft past

Fc Platforms (Dimeric and Monomeric Fc Variants)

pH-Responsive Innovation For Superior Half-Life Extension

Fc platform extends the half-life of protein therapeutics through a best-in-class
pH-responsive mechanism, delivering exceptional PK performance.

Our dimeric Fc or monomeric Fc enables simplicity, efficiency and superior efficacy.
Breakthrough unmatched even by leading global pharmaceutical companies

Firefly_A premium 3D render of a complex protein structure, composed of intertwined alpha-hel 916421.jpg

Biochemical property

 Superior pH-dependent FcRn binding affinity

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IgG1_mFc3

IgG1_mFc11

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MFC3

MFC4

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Dissociation constant (nM), (Log scale)

pH

WT(88,000 nM)

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Physical Properties

Highly homogeneous

75     43      29           13.7 (kDa)

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160     180     200     220     240

Elution volume (ml)

Higly Soluble

Client Fab

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Higly Soluble

Fusion

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mFc

LXL

No aggregation

High thermal stability

T   measurement

10

0

-10

-20

-30

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40       50       60      70       80       90

IgG1_mFc2

IgG1_mFc3

IgG1_mFc4

IgG1_mFc5

[θ]x10   (deg cm dmol)

-3

Temperature (°C)

ScFv18/ScFv2

Higher production

Yield(mg/L)

2500
2000
1500
1000
500
0

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ScFv/ScFv-mFc


ScFv/ScFv

ScFv1/ScFv2 

ScFv18/ScFv2 

m

Progress

Design

Lead

In vivo test

Remarks

Asset

Validation

Fc Platform

Publication

Computational design of monomeric Fc variants with distinct pH-responsive FcRn-binding profiles

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Joon-Young Jeon, Hyejin Lee, Sanghyeon Choi, Seonghyuk Suh, Seong-Bin Im, Yeon-Gil Kim, Bo Mi Ku, Myung-Ju Ahn, Bo-Seong Jeong, Byung-Ha Oh

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