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CATT Platform
Empowering Antibodies with Precision Tumor Targeting
Catenator technology induces reversible antibody catenation by fusing a weakly
homodimerizing protein to the C-terminus of IgG antibodies.
This significantly increases antigen-binding avidity, even at low antigen density,
and can enhance the performance of antibody-based applications,
from rare biomarker detection to targeted anticancer therapies

Mode of Action & In vivo Efficacy

Homodimerization


Measuring
Tumor size, etc
Tumor xenograft
(200~500 mm3)

Original Obinutuzumab
or
Original Obz-catenator

Balb/c mouse

Tumor size (mm3)
Dosage: 1mg/kg
CTL

Tumor size (mm3)
Dosage: 0.1mg/kg
CTL
Obi
1/10 of the dosage
Obi
Obi-Cat
Days after treatment
Obi-Cat
Days after treatment
0 4 7 11 14 18 24
0 4 7 11 14 18 24
1500
1000
500
0
1500
1000
500
0
Progress
POC
Proprietary resarch
Remarks
Asset
application study
CATT Platform
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