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Firefly_High-resolution 3D protein model within a glowing electron density map, _soft past

CATT Platform

Empowering Antibodies with Precision Tumor Targeting

Catenator technology induces reversible antibody catenation by fusing a weakly
homodimerizing protein to the C-terminus of IgG antibodies.

This significantly increases antigen-binding avidity, even at low antigen density,
and can enhance the performance of antibody-based applications,
from rare biomarker detection to targeted anticancer therapies

Firefly_A premium 3D render of a complex protein structure, composed of intertwined alpha-

Mode of Action & In vivo Efficacy

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Homodimerization

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Measuring
Tumor size, etc

Tumor xenograft
(200~500 mm3)

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Original Obinutuzumab
or

Original Obz-catenator

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Balb/c mouse

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Tumor size (mm3)

Dosage: 1mg/kg

CTL

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Tumor size (mm3)

Dosage: 0.1mg/kg

CTL

Obi

1/10 of the dosage

Obi

Obi-Cat

Days after treatment

Obi-Cat

Days after treatment

0    4      7    11   14   18   24

0    4      7    11   14   18   24

1500

1000

500

0

1500

1000

500

0

Progress

POC

Proprietary resarch

Remarks

Asset

application study

CATT Platform

Publication

Noncovalent antibody catenation on a target surface drastically increases the antigen-binding avidity

 

Jinyeop Song, Bo-Seong Jeong, Seong-Woo Kim, Seong-Bin Im, Wonki Cho, Myung-Ju Ahn,

Byung-Ha Oh

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